Role of connexins in infantile hemangiomas
نویسندگان
چکیده
منابع مشابه
Role of connexins in infantile hemangiomas
The circulatory system is one of the first systems that develops during embryogenesis. Angiogenesis describes the formation of blood vessels as a part of the circulatory system and is essential for organ growth in embryogenesis as well as repair in adulthood. A dysregulation of vessel growth contributes to the pathogenesis of many disorders. Thus, an imbalance between pro- and antiangiogenic fa...
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Hemangiomas are common vascular birthmarks that usually present a predictable pattern of proliferation and ultimate involution. Most do not require any treatment. When intervention is clinically indicated, medical and surgical options exist. Historically, corticosteroids have been used and have been shown to slow or stop the growth of a majority of hemangiomas; however, growth concerns and infe...
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Guest Editorial I t is a very exciting time for clini-cians who are confronted with infantile hemangiomas. So much new information is now available regarding pathogenesis, epidemiology, differential diagnosis, and therapy. These aspects are reviewed in greater detail in the accompanying articles by a group of experienced scientists and clinicians, who help provide a richer and more sophisticate...
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Evidence Oral propranolol • In an RCT (40 children, aged 9 weeks to 5 years, followed for 6 months),1 2 mg/kg of propranolol (divided 3 times daily) stopped IH growth by week 4 for all children and reduced IH volume at all weeks compared with placebo (eg, -48.5% vs 17.9% in week 12, P = .03). No significant hypotension, hypoglycemia, or bradycardia were reported. • In a systematic review of 40 ...
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the 5-year event-free survival was 96%. Conservative management is acceptable when surgical resection appears to be curative. In the only fully documented prior case of conjunctival PFL to our knowledge, a 6-year-old boy with a small placoid epibulbar lesion underwent local excision without ancillary chemotherapy or radiotherapy. Three years later, he was disease free as verified by a repeated ...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2013
ISSN: 1663-9812
DOI: 10.3389/fphar.2013.00041